During the 90's with the operation of the Extended Duration Orbiter (EDO), Space Station Freedom (SSF), large platforms in polar and Geosynchronous orbits around the Earth, and supporting systems and technology, an infrastructure will exist that will offer a wide range of opportunities for science and applications payloads. The Marshall Space Flight Center (MSFC) is in a unique position of studying for NASA science missions for all of these systems. This paper will discuss a variety of payloads being studied for NASA at the MSFC that are scheduled for flight in the 90's, in support of space science and Mission to Planet Earth. These science payloads such as the Controls, Astrophysics and Structures Experiment in Space (CASES), Advanced Solar Observatory (ASO), Laser Atmospheric Wind Sounder (LAWS), and Lightning Imaging Sensor (LIS), etc. will fully utilize the capabilities of EDO, SSF, Earth Observing System (EOS), and Earth Science Geostationary Platform (ESGP). Emphasis will be placed on showing how these scientific payloads can fully exploit the great potential of these new capabilities for exciting new science and application missions.